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LWG-301

Product Specifications

Target

Others|||Apoptosis|||Glutaminase

Related Pathways

Proteases/Proteasome|||Others|||Apoptosis

Bioactivity

LWG-301, an allosteric inhibitor of Glutaminase 1 (GLS1), demonstrates a potent inhibition with an IC50 value of 7 nM. It effectively impedes glutamine metabolism and elevates intracellular ROS levels, thereby inducing apoptosis. Additionally, LWG-301 shows moderate antitumor efficacy in the HCT116 xenograft model.

Smiles

CCCCC(=O)NC1=NN=C(S1)NC2CCN(CC2)C3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OCCCC

Molecular Formula

C28H38N8O3S

Molecular Weight

566.72

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

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