DN-1289
Product Specifications
Target
JNK, DNA Alkylation
Related Pathways
DNA Damage/DNA Repair, MAPK
Purity
>99.99%
Bioactivity
DN-1289 is an orally available, blood-brain barrier-crossing, selective and potent inhibitor with an IC50 value of 17 nM for di-leucine zipper kinase (DLK) and 40 nM for leucine zipper-bearing kinase (LZK) .DN-1289 significantly inhibited optic nerve crush (ONC) -induced p-c-Jun in a mouse model.
Smiles
NC1=C(OC(F)F)N=C(C2=NC(N3[C@@H]4CO[C@H](C3)C4)=NC(N5CC(F)(CC5)F)=C2)C=N1
Molecular Formula
C18H19F4N7O2
Molecular Weight
441.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
SL0998Mo-01 48 Tests
Mouse Period Circadian Protein 2 (PER2) ELISA Kit
Sign In for Pricing
View Details SL0998Mo-02 96 Tests
Mouse Period Circadian Protein 2 (PER2) ELISA Kit
Sign In for Pricing
View Details 
LV736568 1.0 µg DNA
NUDT15P1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)
Sign In for Pricing
View Details 
