DN-1289
Product Specifications
Target
JNK, DNA Alkylation
Related Pathways
DNA Damage/DNA Repair, MAPK
Purity
>99.99%
Bioactivity
DN-1289 is an orally available, blood-brain barrier-crossing, selective and potent inhibitor with an IC50 value of 17 nM for di-leucine zipper kinase (DLK) and 40 nM for leucine zipper-bearing kinase (LZK) .DN-1289 significantly inhibited optic nerve crush (ONC) -induced p-c-Jun in a mouse model.
Smiles
NC1=C(OC(F)F)N=C(C2=NC(N3[C@@H]4CO[C@H](C3)C4)=NC(N5CC(F)(CC5)F)=C2)C=N1
Molecular Formula
C18H19F4N7O2
Molecular Weight
441.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
RC229653L4V 200 µL
FAM122B (NM_001170757) Human Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details 
23450062 1.0 µg DNA
HLA-F Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
Sign In for Pricing
View Details 
MBS1274628-01 0.01 mg Plasmid + 0.2 mL Glycerol-Stock
MCM10 cDNA Clone
Sign In for Pricing
View Details MBS1274628-02 5x 0.01 mg Plasmid + 5x 0.2 mL Glycerol-Stock
MCM10 cDNA Clone
Sign In for Pricing
View Details