DN-1289
Product Specifications
Target
JNK|||DNA Alkylation
Related Pathways
DNA Damage/DNA Repair|||MAPK
Purity
>99.99%
Bioactivity
DN-1289 is an orally available, blood-brain barrier-crossing, selective and potent inhibitor with an IC50 value of 17 nM for di-leucine zipper kinase (DLK) and 40 nM for leucine zipper-bearing kinase (LZK) .DN-1289 significantly inhibited optic nerve crush (ONC) -induced p-c-Jun in a mouse model.
Smiles
NC1=C(OC(F)F)N=C(C2=NC(N3[C@@H]4CO[C@H](C3)C4)=NC(N5CC(F)(CC5)F)=C2)C=N1
Molecular Formula
C18H19F4N7O2
Molecular Weight
441.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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