CZS-241
Product Specifications
Target
PLK, Apoptosis, Others, Trk receptor
Related Pathways
Others, Tyrosine Kinase/Adaptors, Apoptosis, Cell Cycle/Checkpoint
Bioactivity
CZS-241 is an orally active, selective Polo-like Kinase (PLK) 4 inhibitor with an IC 50 of 2.6 nM that also inhibits TRKA at an IC 50 of 2.74 μM. It induces apoptosis and causes cell cycle arrest at the S/G2 phase, demonstrating potent antiproliferative effectiveness against leukemia cell lines while maintaining safety towards normal cell lines.
Smiles
CC1=CC(=NN1)NC2=C3C=NN(C3=NC(=N2)NCC4=CC(=C(C=C4)Cl)C(=O)NC5=C(C=CC(=C5)F)F)C(C)C
Molecular Formula
C26H24ClF2N9O
Molecular Weight
551.98
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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