CFT8634
Product Specifications
CAS Number
2704617-96-7
Target
PROTACs, Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic, PROTAC
Bioactivity
CFT8634 is an orally active and selective degrader targeting BRD9, with effects on the proliferation of SMARCB1-deficient cancer cell lines. CFT8634 induces the formation of a ternary complex with BRD9 and E3 ligase, inducing BRD9 ubiquitination and subsequent degradation by the proteasome.
Smiles
CC=1C(C2=CC(OC)=C(CN3CC(F)(F)[C@H](CC3)N4CCN(CC4)C5=C(F)C=C(N[C@@H]6C(=O)NC(=O)CC6)C=C5)C(OC)=C2)=CN(C)C(=O)C1C
Molecular Formula
C37H45F3N6O5
Molecular Weight
710.79
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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