PV-1019
Product Specifications
CAS Number
1093793-05-5
Target
Chk|||Others
Related Pathways
Cell Cycle/Checkpoint|||Others
Bioactivity
PV-1019 (NSC 744039) is a potent and selective inhibitor of Chk2 with an IC50 of 24 nM, effectively inhibiting Topotecan-induced Chk2 autophosphorylation and suppressing IR-induced apoptosis [1].
Smiles
N(=O)(=O)C1=C2C(C=C(C(NC3=CC=C(C(=NNC(=N)N)C)C=C3)=O)N2)=CC=C1
Molecular Formula
C18H17N7O3
Molecular Weight
379.37
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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