SZM-1209
Product Specifications
CAS Number
2919801-86-6
Target
MLK, Necroptosis, RIP kinase
Related Pathways
NF-κB, Apoptosis, MAPK
Bioactivity
SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM. It demonstrates substantial anti-necroptotic efficacy with an EC50 of 22.4 ± 8.1 nM and possesses therapeutic effects against systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI) [1].
Molecular Formula
C31H29F5N4O5S2
Molecular Weight
696.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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