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Articaine

Product Specifications

CAS Number

23964-58-1

Target

Sodium Channel, Others, NOD-like Receptor (NLR), NF-κB

Related Pathways

Immunology/Inflammation, Others, NF-κB, Membrane transporter/Ion channel

Bioactivity

Articaine (Hoe-045 free base), an amide anesthetic featuring an ester group, effectively relieves pain by reversibly binding to the α-subunit of the voltage-gated sodium channels located in the nerve's inner cavity. Furthermore, Articaine mitigates LPS-induced acute kidney injury through the suppression of NF-κB activation and inhibition of the NLRP3 inflammasome pathway.

Smiles

CCCNC(C)C(=O)NC1=C(SC=C1C)C(=O)OC

Molecular Formula

C13H20N2O3S

Molecular Weight

284.37

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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