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BTK-IN-17

Product Specifications

Target

Others, BTK

Related Pathways

Angiogenesis, Others, Tyrosine Kinase/Adaptors

Bioactivity

BTK-IN-17 is a selective, orally active inhibitor of Bruton's Tyrosine Kinase (BTK) with an inhibition concentration (IC50) value of 13.7 nM. It effectively reduces the expression of phosphorylated BTK at Tyrosine 223 (p-BTK Y223) and phosphorylated Phospholipase C Gamma 2 at Tyrosine 1217 (p-PLCγ2 Y1217), demonstrating anti-inflammatory properties.

Smiles

C=CC(=O)N1CC[C@H](C1)N2C3=C4C(=CN=C4NC=N3)C(=N2)NC5=CC=C(C=C5)OC6=CC=CC=C6

Molecular Formula

C26H23N7O2

Molecular Weight

465.51

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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