What is the catalog number for ATR-IN-20?

The catalog number for ATR-IN-20 is T73301.

What sizes are available for ATR-IN-20?

ATR-IN-20 is available in the following size(s): 25 mg, 50 mg, 100 mg.

How many pack sizes does ATR-IN-20 come in?

ATR-IN-20 is available in 3 different pack sizes.

Is ATR-IN-20 in stock?

ATR-IN-20 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures ATR-IN-20?

ATR-IN-20 is manufactured by Molfinity.

What is the estimated delivery time for ATR-IN-20?

Estimated delivery time for ATR-IN-20 is approximately 10 business day(s), depending on your location.

ATR-IN-20

Product Specifications

Target

Others, mTOR, ATM/ATR

Related Pathways

DNA Damage/DNA Repair, Others, PI3K/Akt/mTOR signaling

Bioactivity

ATR-IN-20, a potent ATM/ATR inhibitor, showcases an IC50 value of 3 nM. It also exhibits inhibitory activity against mTOR with an IC50 of 18 nM, while maintaining selectivity over PI3Kα (100 nM), ATM (100 nM), and DNA-PK (662 nM) . Additionally, ATR-IN-20 has an excellent pharmacokinetic profile with an oral bioavailability (F) of 30%, and demonstrates anticancer effects.