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ATR-IN-20

Product Specifications

Target

Others|||mTOR|||ATM/ATR

Related Pathways

DNA Damage/DNA Repair|||Others|||PI3K/Akt/mTOR signaling

Bioactivity

ATR-IN-20, a potent ATM/ATR inhibitor, showcases an IC50 value of 3 nM. It also exhibits inhibitory activity against mTOR with an IC50 of 18 nM, while maintaining selectivity over PI3K? (100 nM), ATM (100 nM), and DNA-PK (662 nM) . Additionally, ATR-IN-20 has an excellent pharmacokinetic profile with an oral bioavailability (F) of 30%, and demonstrates anticancer effects.

Smiles

C[C@@H]1COCCN1C2=NC(=NC3=C2CN(C3(C)C)C(=O)C4=CC(=CC=C4)S(=O)(=O)C)C5=C6C=CNC6=CC=C5

Molecular Formula

C29H31N5O4S

Molecular Weight

545.65

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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