AXL-IN-13

Product Specifications

CAS Number

2376928-82-2

Target

FLT|||PDGFR|||TAM Receptor|||TGF-beta/Smad

Related Pathways

Tyrosine Kinase/Adaptors|||Stem Cells|||Angiogenesis

Purity

0.9995

Bioactivity

AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 of 1.6 nM and a Kd of 0.26 nM. It exhibits anticancer activity, reverses TGF-?1-induced epithelial-mesenchymal transition (EMT), and inhibits cancer cell migration and invasion.

Smiles

O(C=1C2=C(C=C(OCCCN3CCOCC3)C(OC)=C2)N=CC1)C4=C(F)C=C(NC=5C(C(NC6CCCCC6)=O)=CN(C)N5)C=C4

Molecular Formula

C34H41FN6O5

Molecular Weight

632.72

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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