AXL-IN-13
Product Specifications
CAS Number
2376928-82-2
Target
FLT|||PDGFR|||TAM Receptor|||TGF-beta/Smad
Related Pathways
Tyrosine Kinase/Adaptors|||Stem Cells|||Angiogenesis
Purity
0.9995
Bioactivity
AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 of 1.6 nM and a Kd of 0.26 nM. It exhibits anticancer activity, reverses TGF-?1-induced epithelial-mesenchymal transition (EMT), and inhibits cancer cell migration and invasion.
Smiles
O(C=1C2=C(C=C(OCCCN3CCOCC3)C(OC)=C2)N=CC1)C4=C(F)C=C(NC=5C(C(NC6CCCCC6)=O)=CN(C)N5)C=C4
Molecular Formula
C34H41FN6O5
Molecular Weight
632.72
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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