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APE1-IN-2

Product Specifications

CAS Number

2923433-95-6

Target

MDM-2/p53, Apoptosis

Related Pathways

Apoptosis

Bioactivity

APE1-IN-2 (compound AP1), a Pt (IV) proagent, selectively targets the essential base excision repair protein apurinic/apyrimidinic endonuclease 1 (APE1) . Exhibiting anticancer properties, APE1-IN-2 prompts the intracellular accumulation of platinum and initiates the activation of DNA damage response and apoptosis pathways [1].

Smiles

O=[N+](C1=CC=CC2=C1NC(C(O[Pt]([NH3])(Cl)(O)(Cl)[NH3])=O)=C2)[O-]

Molecular Formula

C9H12Cl2N4O5Pt

Molecular Weight

522.21

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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