APE1-IN-2
Product Specifications
CAS Number
2923433-95-6
Target
MDM-2/p53|||Apoptosis
Related Pathways
Apoptosis
Bioactivity
APE1-IN-2 (compound AP1), a Pt (IV) proagent, selectively targets the essential base excision repair protein apurinic/apyrimidinic endonuclease 1 (APE1) . Exhibiting anticancer properties, APE1-IN-2 prompts the intracellular accumulation of platinum and initiates the activation of DNA damage response and apoptosis pathways [1].
Smiles
O=[N+](C1=CC=CC2=C1NC(C(O[Pt]([NH3])(Cl)(O)(Cl)[NH3])=O)=C2)[O-]
Molecular Formula
C9H12Cl2N4O5Pt
Molecular Weight
522.21
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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