USP7-IN-9
Product Specifications
Target
Others, DUB, Apoptosis
Related Pathways
DNA Damage/DNA Repair, Ubiquitination, Cell Cycle/Checkpoint, Others, Apoptosis
Bioactivity
USP7-IN-9, a potent inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 40.8 nM, effectively induces apoptosis and arrests cell progression at the G0/G1 and S phases in RS4;11 cells. It decreases the protein levels of oncoproteins MDM2 and DNMT1 while enhancing the levels of tumor suppressors p53 and p21.
Smiles
COC(C1=CC=C(C[NH+]2CCC(CC2)(O)CN(C=NC3=C4C5=CC=C(C[NH3+])C=C5)C(C3=NN4C)=O)C(Cl)=C1)=O.O=C([O-])C(F)(F)F.O=C([O-])C(F)(F)F
Molecular Formula
C32H33ClF6N6O8
Molecular Weight
779.08
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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