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OTS193320

Product Specifications

CAS Number

2093401-33-1

Target

Apoptosis, Histone Methyltransferase, Others

Related Pathways

Chromatin/Epigenetic, Others, Apoptosis

Bioactivity

OTS193320, an imidazopyridine compound, acts as an inhibitor of SUV39H2 methyltransferase activity. It effectively reduces global histone H3 lysine 9 tri-methylation levels in breast cancer cells, promoting apoptotic cell death. When combined with Doxorubicin (DOX), OTS193320 enhances the reduction of γ-H2AX levels and decreases cancer cell viability more significantly than when either agent is used alone.

Smiles

O(C)C1=C(C2=CN3C(=N2)C=C(N[C@@H]4CC[C@H](NCC5=CC=C(N(=O)=O)C=C5)CC4)C=C3)C=C(Cl)C(OC)=C1

Molecular Formula

C28H30ClN5O4

Molecular Weight

536.02

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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