BMS-986339
Product Specifications
CAS Number
2477873-64-4
Target
Others, Cytochromes P450, FXR
Related Pathways
Metabolism, Others
Bioactivity
BMS-986339 is an orally active, potent FXR agonist that engages His298 and ASN287 residues via H-bond formation. It is employed in research on primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and nonalcoholic steatohepatitis (NASH) due to its anti-fibrosis properties.
Smiles
C(C)(C)(F)C1=NC(C23CCC(CN(C(=O)[C@H]4C[C@@](C(F)(F)F)(O)C4)C5=CC(=CC=C5)C6=CC=C(C(C)(C)O)C=C6)(CC2)CC3)=NO1
Molecular Formula
C35H41F4N3O4
Molecular Weight
643.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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