HPK1-IN-33
Product Specifications
CAS Number
2920000-86-6
Target
Others, MAPK
Related Pathways
Others, MAPK
Bioactivity
HPK1-IN-33 (compound 21), a Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor, exhibits a high potency with a K_i of 1.7 nM. It effectively inhibits IL-2 production, demonstrating EC_50 values of 286 nM in Jurkat WT cells and >10000 nM in Jurkat HPK1 KO cells [1].
Smiles
N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CC[C@@H](F)[C@@H](N)C4)c23)c1
Molecular Formula
C18H16ClFN6
Molecular Weight
370.81
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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