EZH2-IN-14
Product Specifications
CAS Number
1979157-17-9
Target
Histone Methyltransferase, Others
Related Pathways
Chromatin/Epigenetic, Others
Bioactivity
EZH2-IN-14 is a selective inhibitor of EZH2 (Histone Methyltransferase) with an IC50 value of 12 nM, targeting the methyltransferase activity of EZH2/PRC2 and reducing H3K27me3 levels. It exhibits more than 200-fold selectivity for EZH2 over the closely related H3K27 methyltransferase, EZH1.
Smiles
C(C)(C)N1C=2C(=C(C(NCC3=C(C)C=C(C)NC3=O)=O)C=C(C2)C=4C=CC(=NC4)N5CCN(C(C)C)CC5)C=N1
Molecular Formula
C31H39N7O2
Molecular Weight
541.69
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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