EGFR-IN-61
Product Specifications
CAS Number
2890261-81-9
Target
EGFR
Related Pathways
Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors
Bioactivity
EGFR-IN-61 (compound 22a), a potent EGFR kinase inhibitor, exhibits IC50 values of 42 nM for L858R/T790M, 137 nM for L858R/T790M/C797S, and 743 nM for WT. Additionally, it demonstrates antiproliferative activity against the A549 and H1975 cell lines, with IC50 values of 2.14 ?M and 1.82 ?M, respectively [1].
Smiles
CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C2=CC(=NC=C2)Cl)NC3=NC=CC(=N3)C4=CN(C5=CC=CC=C54)CCCO)OC
Molecular Formula
C33H37ClN8O3
Molecular Weight
629.15
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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