SMTIN-T140
Product Specifications
CAS Number
2851532-40-4
Target
AMPK|||HSP|||Reactive Oxygen Species
Related Pathways
Metabolism|||Cytoskeletal Signaling|||NF-?B|||Chromatin/Epigenetic|||PI3K/Akt/mTOR signaling|||Immunology/Inflammation
Bioactivity
SMTIN-T140 (compound 6a), a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor with an IC50 of 1.646 ?M, exhibits anticancer activity by inducing mitochondrial dysfunction, elevating mitochondrial ROS production, and activating AMPK. Notably, SMTIN-T140 effectively suppressed tumor growth without discernible in vivo toxicity in a PC3 prostate cancer cell-xenografted mouse model [1].
Smiles
C1=CC=C(C=C1)[P+](CCCCCCN2C3=C(N=C(N=C3Cl)N)N(C2=O)CC4=C(C=C(C=C4)Br)F)(C5=CC=CC=C5)C6=CC=CC=C6
Molecular Formula
C36H34BrClFN5OP+
Molecular Weight
718.02
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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