Talotrexin
Product Specifications
CAS Number
113857-87-7
Target
DHFR, Others, Antifolate
Related Pathways
Cell Cycle/Checkpoint, Metabolism, Others, DNA Damage/DNA Repair
Bioactivity
Talotrexin (PT523), an analog of Aminopterin, is a nonpolyglutamatable classic antifolate that specifically inhibits the reduced folate carrier (RFC), selectively impeding RFC transport and targeting dihydrofolate reductase (DHFR) to demonstrate antitumor activity and inhibit tumor growth [1] [2].
Smiles
NC=1C2=C(N=CC(CNC3=CC=C(C(N[C@@H](CCCNC(=O)C4=C(C(O)=O)C=CC=C4)C(O)=O)=O)C=C3)=N2)N=C(N)N1
Molecular Formula
C27H27N9O6
Molecular Weight
573.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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