(S) -V-0219
Product Specifications
Target
Glucagon Receptor|||Others
Related Pathways
GPCR/G Protein|||Others
Bioactivity
(S) -V-0219, an enantiomer of V-0219, is an orally active positive allosteric modulator (PAM) of the GLP-1 Receptor (GLP-1R) . It activates calcium fluxes in HEK cells stably expressing hGLP-1R, demonstrating its oral activity. Additionally, (S) -V-0219 ameliorates high glucose levels in mice and inhibits feeding behavior in fasted mice [1].
Smiles
C1C[C@H](CN(C1)CC2=NC(=NO2)C3=CC=C(C=C3)C(F)(F)F)CN4CCOCC4
Molecular Formula
C20H25F3N4O2
Molecular Weight
410.43
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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