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(S) -V-0219

Product Specifications

Target

Glucagon Receptor|||Others

Related Pathways

GPCR/G Protein|||Others

Bioactivity

(S) -V-0219, an enantiomer of V-0219, is an orally active positive allosteric modulator (PAM) of the GLP-1 Receptor (GLP-1R) . It activates calcium fluxes in HEK cells stably expressing hGLP-1R, demonstrating its oral activity. Additionally, (S) -V-0219 ameliorates high glucose levels in mice and inhibits feeding behavior in fasted mice [1].

Smiles

C1C[C@H](CN(C1)CC2=NC(=NO2)C3=CC=C(C=C3)C(F)(F)F)CN4CCOCC4

Molecular Formula

C20H25F3N4O2

Molecular Weight

410.43

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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