Phanginin A
Product Specifications
CAS Number
1011528-58-7
Target
SIK
Related Pathways
PI3K/Akt/mTOR signaling
Purity
0.9554
Bioactivity
Phanginin A, a natural product discovered in Caesalpinia sappan Linn, activates SIK1 and inhibits gluconeogenesis in mouse primary hepatocytes. Phanginin A increases PDE4 activity and suppresses the hepatic cAMP/PKA/CREB pathway, improving metabolic disorders in ob/ob mice. It may be used in studies of type 2 diabetes.
Smiles
O[C@H]1[C@@]23[C@]([C@@](C(OC)=O)(CO1)CCC2)(CC[C@@]4([C@@]3(CC5=C([C@@H]4C)C=CO5)[H])[H])[H]
Molecular Formula
C21H28O5
Molecular Weight
360.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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