PARP1-IN-12
Product Specifications
Target
PARP, Apoptosis, Others
Related Pathways
Apoptosis, DNA Damage/DNA Repair, Chromatin/Epigenetic, Others
Bioactivity
PARP1-IN-12, a potent inhibitor of PARP1, demonstrates an IC50 value of 2.99 nM. It exhibits antiproliferative effects, induces apoptosis, and causes cell cycle arrest in the G2/M phase. Additionally, PARP1-IN-12 induces DNA double-strand breaks (DSBs) in BRCA-deficient cells.
Smiles
C[C@H]1CCC[C@@]2(C)C1=CC3C(OC(C3CNCCCCCCCC(N4CCN(C(C5=C(F)C=CC(CC6=NNC(C7C6C=CC=C7)=O)=C5)=O)CC4)=O)=O)C2
Molecular Formula
C43H56FN5O5
Molecular Weight
741.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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