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C-Met-IN-14

Product Specifications

CAS Number

2443380-34-3

Target

C-Met/HGFR, Apoptosis, FLT, Others, c-Kit

Related Pathways

Apoptosis, Angiogenesis, Tyrosine Kinase/Adaptors, Others

Bioactivity

C-Met-IN-14, a N-sulfonylamidine-based derivative, is a selective c-Met kinase inhibitor with an IC50 value of 2.89 nM. It exhibits anticancer properties by inhibiting c-Met phosphorylation and arresting the cell cycle at the G2/M phase. Additionally, c-Met-IN-14 promotes dose-dependent apoptosis in A549 cells.

Smiles

O(C=1C2=C(C=C(OCCCN3CCOCC3)C(OC)=C2)N=CC1)C4=C(F)C=C(N=C(NS(CC5=CC=C(Cl)C=C5)(=O)=O)CCOC)C=C4

Molecular Formula

C34H38ClFN4O7S

Molecular Weight

701.2

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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