C-Met-IN-14
Product Specifications
CAS Number
2443380-34-3
Target
C-Met/HGFR|||Apoptosis|||FLT|||Others|||c-Kit
Related Pathways
Apoptosis|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Others
Bioactivity
C-Met-IN-14, a N-sulfonylamidine-based derivative, is a selective c-Met kinase inhibitor with an IC50 value of 2.89 nM. It exhibits anticancer properties by inhibiting c-Met phosphorylation and arresting the cell cycle at the G2/M phase. Additionally, c-Met-IN-14 promotes dose-dependent apoptosis in A549 cells.
Smiles
O(C=1C2=C(C=C(OCCCN3CCOCC3)C(OC)=C2)N=CC1)C4=C(F)C=C(N=C(NS(CC5=CC=C(Cl)C=C5)(=O)=O)CCOC)C=C4
Molecular Formula
C34H38ClFN4O7S
Molecular Weight
701.2
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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