SIRT2-IN-11
Product Specifications
CAS Number
1005095-06-6
Target
Others, Sirtuin
Related Pathways
Others, DNA Damage/DNA Repair, Chromatin/Epigenetic
Bioactivity
SIRT2-IN-11 (AEM1) is a selective inhibitor of SIRT2 with an inhibitory concentration (IC50) of 18.5 μM. It induces apoptosis in a p53-dependent manner, activates the expression of CDKN1A, PUMA, and NOXA, and enhances the acetylation of p53. This compound is utilized in the study of p53-associated cancers.
Smiles
C(N)(=O)C=1C=C2C3C(C(NC2=CC1)C4=CC=CC=C4)C5CC3CC5
Molecular Formula
C21H22N2O
Molecular Weight
318.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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