LEM-14-1189
Product Specifications
CAS Number
2987501-17-5
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Purity
0.9806
Bioactivity
Lem-14-1189, a LEM-14 derivative, is a potent NSD inhibitor of the nuclear receptor binding SET domain, and has inhibitory effects on NSD1, NSD2, and NSD3, with IC50 of 418 ?M, 111 ?M, and 60 ?M, respectively. LEM-14-1189 has potential anticancer activity and can be used to study multiple myeloma (MM) and diseases of the blood system.
Smiles
C1CCC2=C(C1)C3=C(S2)N=C(NC3=O)CN(CCCNC(=O)C4=CC5=CC=CC=C5C(=O)O4)CC6=NC7=C(C8=C(S7)CCCC8)C(=O)N6
Molecular Formula
C35H34N6O5S2
Molecular Weight
682.81
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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