Darizmetinib
Product Specifications
Target
P38 MAPK|||Antiviral|||NF-?B|||MDM-2/p53|||JNK|||MAPK
Related Pathways
NF-?B|||Immunology/Inflammation|||MAPK|||Apoptosis
Purity
0.9957
Bioactivity
Darizmetinib (HRX215, HRX-0215) is an MKK4 inhibitor. Inhibition of MKK4 leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration.
Smiles
O=C(C1=NNC2=NC=C(C=C21)C=3C=CN=CC3)C4=CC=C(F)C(NS(=O)(=O)CCC)=C4F
Molecular Formula
C21H17F2N5O3S
Molecular Weight
457.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/62151357645193274/T72956
CAS Number
2369583-33-3
Available Sizes
Curated Selection
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