CDK4/6-IN-14
Product Specifications
CAS Number
2699091-15-9
Target
Others, CDK
Related Pathways
Cell Cycle/Checkpoint, Others
Bioactivity
CDK4/6-IN-14 is a potent, highly selective inhibitor of Cyclin-Dependent Kinases 4 and 6 (CDK4/6), with inhibition concentrations (IC50s) of 10 nM and 16 nM, respectively. It shows over 60-fold selectivity for CDK4/6 compared to CDKs 1, 2, 7, and 9, and exhibits significant selectivity against 205 other kinases.
Smiles
Cl.O=C1C=2C=CC(=CC2CCN1CC)C3=NC(=NC=C3F)NC4=NC=C(C=C4)N5CCNCC5
Molecular Formula
C24H27ClFN7O
Molecular Weight
483.97
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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