EIF4A3-IN-17
Product Specifications
CAS Number
1402931-75-2
Target
PERK, Others
Related Pathways
Others, Apoptosis
Bioactivity
EIF4A3-IN-17, a silvestrol analogue, disrupts the assembly of the eIF4F translation complex, exhibiting EC50 values of 0.9, 15, and 1.8 nM for myc-LUC, tub-LUC, and growth inhibition of MBA-MB-231 cells, respectively. This compound holds potential for research in human cancer pathogenesis [1].
Smiles
O[C@]12[C@]([C@@H]([C@@H](C(OC)=O)[C@H]1O)C3=CC=CC=C3)(OC=4C2=C(OC)C=C(C#N)C4)C5=CC=C(OC)C=C5
Molecular Formula
C28H25NO7
Molecular Weight
487.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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