TRK/ALK-IN-1
Product Specifications
Target
ALK, Others, Trk receptor
Related Pathways
Angiogenesis, Others, Tyrosine Kinase/Adaptors
Bioactivity
TRK/ALK-IN-1 is a potent dual inhibitor of TRK and ALK, exhibiting good correlation between its enzymatic inhibition and anti-proliferative activities, with IC50 values of 2.2 nM for TRKA, 9.3 nM for ALK WT, and 38 nM for ALK L1196M. It holds potential for cancer research applications.
Smiles
CN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)[C@@H]3CCCN3C4=NC(=NC=C4Cl)NC5=CC(=CC(=C5)F)F)C(=O)N6CCSCC6
Molecular Formula
C31H35ClF2N8O2S
Molecular Weight
657.18
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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