CDK4/6-IN-15
Product Specifications
CAS Number
2078047-99-9
Target
Others, CDK
Related Pathways
Others, Cell Cycle/Checkpoint
Bioactivity
CDK4/6-IN-15, an orally active and selective inhibitor of CDK4/6, effectively halts the growth of cancer cells by arresting the cell cycle at the G1 phase and inhibiting the phosphorylation of the retinoblastoma tumor suppressor protein (Rb) at S780, as well as suppressing E2 factor (E2F) -regulated gene expression.
Smiles
CC1=C(SC(NC)=N1)C2=NC(NC3=CC=C(C=N3)N4CCC(N(C)C)CC4)=NC=C2F
Molecular Formula
C21H27FN8S
Molecular Weight
442.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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