VEGFR-3-IN-1
Product Specifications
CAS Number
2756668-73-0
Target
VEGFR
Related Pathways
Angiogenesis|||Tyrosine Kinase/Adaptors
Purity
0.9995
Bioactivity
VEGFR-3-IN-1 is a novel, potent, and selective VEGFR3 inhibitor with an IC50 of 110.4 nM. It exhibits antitumor activity, inactivates the VEGFR3 signaling pathway, and inhibits the proliferation and migration of VEGF-C-induced human dermal lymphatic endothelial cells (HDLEC), MDA-MB-231, and MDA-MB-436 cells.
Smiles
C(NC1=CC(C(F)(F)F)=C(Cl)C=C1)(=O)N2CCN(C3=C4C(SC(=C4)C5=CC=C(C=C5)N6CCN(C)CC6)=NC=N3)CC2
Molecular Formula
C29H29ClF3N7OS
Molecular Weight
616.1
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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