SEH/AChE-IN-3
Product Specifications
CAS Number
2490589-11-0
Target
Others, Epoxide Hydrolase, Cholinesterase (ChE)
Related Pathways
Neuroscience, Others, Metabolism
Bioactivity
SEH/AChE-IN-3 (15) serves as a dual inhibitor targeting both soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE), demonstrating potent activity and the ability to cross the blood-brain barrier (BBB) . It exhibits IC50 values of 0.4 nM for human sEH (hsEH), 1.94 nM for human AChE (hAChE), 615 nM for human butyrylcholinesterase (hBChE), 4.3 nM for mouse sEH (msEH), and 2.61 nM for mouse AChE (mAChE), indicating its efficacy across these enzymes.
Smiles
N(CCCCC(=O)N1CCC(NC(NC2=CC=C(OC(F)(F)F)C=C2)=O)CC1)C3=C4C(=NC=5C3=CC=C(Cl)C5)C[C@@]6(C[C@]4(CC(C)=C6)[H])[H]
Molecular Formula
C35H39ClF3N5O3
Molecular Weight
670.16
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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