Sofnobrutinib
Product Specifications
CAS Number
1646608-10-7
Target
Others
Related Pathways
Others
Bioactivity
Sofnobrutinib (AS-0871) is an orally active, selective inhibitor of Bruton's tyrosine kinase (BTK) with IC50 values of 4.2 nM for activated BTK and 0.39 nM for unactivated BTK. It has an IC50 of 24 μM against hERG, exhibits strong metabolic stability and bioavailability, induces a weak passive cutaneous anaphylaxis reaction, and demonstrates anti-inflammatory properties in a mouse model of collagen-induced arthritis.
Smiles
C(O)C1=C(C=CC=C1C=2N=C(NC3=CN(C)N=C3)N=C(N)N2)N4C(=O)C=5C(C=C4)=CC(=CC5F)C6CC6
Molecular Formula
C26H23FN8O2
Molecular Weight
498.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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