SHP2/HDAC-IN-1
Product Specifications
CAS Number
2831230-38-5
Target
Others, Phosphatase, HDAC
Related Pathways
Others, Chromatin/Epigenetic, DNA Damage/DNA Repair, Metabolism
Bioactivity
SHP2/HDAC-IN-1, a dual allosteric inhibitor targeting SHP2 and HDAC, exhibits potent inhibitory effects with IC 50 values of 20.4 nM (SHP2) and 25.3 nM (HDAC1), respectively. This compound activates T cells, enhances antigen presentation, and promotes cytokine secretion, facilitating efficient antitumor immunity. It holds potential for cancer immunotherapy research.
Smiles
ClC1=C(C=CC=C1Cl)C=2C(N)=NC(=CN2)N3CCC(NCC4=CC=C(C(NCC5=CC=C(/C=C/C(NO)=O)C=C5)=O)C=C4)(C)CC3
Molecular Formula
C34H35Cl2N7O3
Molecular Weight
660.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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