SHP2/CDK4-IN-1
Product Specifications
CAS Number
2924036-87-1
Target
Phosphatase|||Others|||CDK
Related Pathways
Others|||Cell Cycle/Checkpoint|||Metabolism
Bioactivity
SHP2/CDK4-IN-1 (compound 10) is a dual inhibitor targeting SHP2 and CDK4, with oral activity and high potency, showing IC50 values of 4.3 nM for SHP2 and 18.2 nM for CDK4. It induces G0/G1 arrest, inhibits proliferation of TNBC cell lines, and demonstrates significant antitumor efficacy in the EMT6 syngeneic mouse model. This compound is valuable for research into triple-negative breast cancer (TNBC) [1].
Smiles
C[C@H]1[C@H](C2(CCN(CC2)C3=CN=C(C=N3)SC4=C(C(=NC=C4)NC5=NC=C(C(=N5)C6=CC7=C(C(=C6)F)N=C(N7C(C)C)C)F)Cl)CO1)N
Molecular Formula
C33H35ClF2N10OS
Molecular Weight
693.21
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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