C-Met/HDAC-IN-2
Product Specifications
CAS Number
2740495-53-6
Target
Others|||Apoptosis|||c-Met/HGFR|||HDAC
Related Pathways
DNA Damage/DNA Repair|||Chromatin/Epigenetic|||Apoptosis|||Others|||Tyrosine Kinase/Adaptors
Bioactivity
C-Met/HDAC-IN-2 is a potent dual inhibitor of c-Met and HDAC, exhibiting IC50 values of 5.40 nM for c-Met and 18.49 nM for HDAC1, respectively. It demonstrates antiproliferative effects on various cancer cell lines, induces G2/M-phase arrest, and triggers apoptosis in HCT-116 cells, making it a promising candidate for anti-cancer resistance research.
Smiles
O(C=1C2=C(C=C(OCCCCCCC(NO)=O)C(OC)=C2)N=CC1)C3=CC=C(NC(=O)C4=NN(C=CC4=O)C5=CC=CC=C5)C=C3
Molecular Formula
C34H33N5O7
Molecular Weight
623.66
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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