JNK3 inhibitor-4
Product Specifications
CAS Number
2409109-65-3
Target
Others, JNK
Related Pathways
MAPK, Others
Bioactivity
JNK3 Inhibitor-4, a potent 2-aryl-1-pyrimidinyl-1H-imidazole-5-yl acetonitrile derivative, demonstrates a strong inhibitory effect on JNK3 with an IC 50 value of 1.0 nM. It exhibits exceptional selectivity against JNK3 when compared to other protein kinases, including isoforms JNK1 (IC 50 = 143.9 nM) and JNK2 (IC 50 = 298.2 nM) . Additionally, JNK3 Inhibitor-4 benefits from neuroprotective properties and is predicted to permeate the blood-brain barrier effectively.
Smiles
C(C#N)C=1N(C(=NC1)C2=CC3=C(C=C2)C=CC=C3)C4=NC(N[C@@H]5CN(C(=O)C6CC6)CCC5)=NC=C4
Molecular Formula
C28H27N7O
Molecular Weight
477.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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