(Rac) -Lonafarnib
Product Specifications
CAS Number
193275-86-4
Target
Others, Transferase
Related Pathways
Others, Metabolism
Bioactivity
(Rac) -Lonafarnib (Sch66336 racemate) is the racemic form of the potent, orally active farnesyl transferase (FTase) inhibitor, Lonafarnib. It effectively inhibits H-ras, K-ras, and N-ras with IC50 values of 1.9 nM, 5.2 nM, and 2.8 nM, respectively, and exhibits activities against the hepatitis delta virus (HDV) .
Smiles
BrC1=C2C(C=3C(CCC2=CC(Cl)=C1)=CC(Br)=CN3)C4CCN(C(CC5CCN(C(N)=O)CC5)=O)CC4
Molecular Formula
C27H31Br2ClN4O2
Molecular Weight
638.82
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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