Keap1-Nrf2-IN-13
Product Specifications
CAS Number
2456294-92-9
Target
Others|||Nrf2
Related Pathways
Immunology/Inflammation|||Others
Bioactivity
Keap1-Nrf2-IN-13 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with an IC50 value of 0.15 ?M, indicating high efficacy. It binds strongly to Keap1 by forming hydrogen bonds with critical polar residues (Asn414, Arg415, Arg483, Gln530), showcasing specificity. This compound has implications for research into diseases associated with oxidative stress and inflammation, such as pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), and cancers, due to its mechanism of action.
Smiles
N(S(=O)(=O)C1=CC=C(OC)C=C1)(CC2=C(CN(S(=O)(=O)C3=CC=C(OC)C=C3)[C@H](C(O)=O)C)C=CC=C2)[C@H](C(O)=O)C
Molecular Formula
C28H32N2O10S2
Molecular Weight
620.69
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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