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UCK2 Inhibitor-3

Product Specifications

CAS Number

2376687-49-7

Target

DNA/RNA Synthesis, Others

Related Pathways

Cell Cycle/Checkpoint, Others, DNA Damage/DNA Repair

Bioactivity

UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2), a pivotal enzyme in the pyrimidine salvage pathway, with an IC50 value of 16.6 μM. UCK2 can partially substitute for dihydroorotate dehydrogenase (DHODH) in infected or rapidly dividing cells, aiding uridine salvage. Additionally, UCK2 Inhibitor-3 inhibits DNA polymerase eta and kappa, with IC50 values of 56 μM and 16 μM, respectively.

Smiles

O=C1N=C(N=C2C1=CNN2C3=CC=C(F)C=C3)SCC(=O)NC4=CC=C(Br)C=C4

Molecular Formula

C19H13BrFN5O2S

Molecular Weight

474.31

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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