UCK2 Inhibitor-3
Product Specifications
CAS Number
2376687-49-7
Target
DNA/RNA Synthesis, Others
Related Pathways
Cell Cycle/Checkpoint, Others, DNA Damage/DNA Repair
Bioactivity
UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2), a pivotal enzyme in the pyrimidine salvage pathway, with an IC50 value of 16.6 μM. UCK2 can partially substitute for dihydroorotate dehydrogenase (DHODH) in infected or rapidly dividing cells, aiding uridine salvage. Additionally, UCK2 Inhibitor-3 inhibits DNA polymerase eta and kappa, with IC50 values of 56 μM and 16 μM, respectively.
Smiles
O=C1N=C(N=C2C1=CNN2C3=CC=C(F)C=C3)SCC(=O)NC4=CC=C(Br)C=C4
Molecular Formula
C19H13BrFN5O2S
Molecular Weight
474.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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