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Keap1-Nrf2-IN-11

Product Specifications

CAS Number

2796292-75-4

Target

Others|||Nrf2|||ROS Kinase|||NO Synthase

Related Pathways

Tyrosine Kinase/Adaptors|||Others|||Immunology/Inflammation

Bioactivity

Keap1-Nrf2-IN-11 (Compound 6k), a potent Keap1-Nrf2 inhibitor, exhibits a dissociation constant (KD) of 0.21 nM. It hampers the production of reactive oxygen species (ROS) and nitric oxide (NO), as well as the expression of tumor necrosis factor-alpha (TNF-?) . By promoting Nrf2 nuclear translocation, it mitigates inflammation and is utilized in anti-inflammatory studies [1].

Smiles

CCN1CCN(CC1)CCC(=O)NC2=CC=C(C=C2)S(=O)(=O)N(CC(=O)N)C3=CC=C(C4=CC=CC=C43)N(CC(=O)N)S(=O)(=O)C5=CC=C(C=C5)OC

Molecular Formula

C36H43N7O8S2

Molecular Weight

765.9

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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