PD-1/PD-L1-IN-27
Product Specifications
CAS Number
2891831-47-1
Target
PD-1/PD-L1
Related Pathways
Immunology/Inflammation, Apoptosis, Cell Cycle/Checkpoint
Bioactivity
PD-1/PD-L1-IN-27 is a potent inhibitor of PD-1/PD-L1, with an IC50 of 134 nM, and demonstrates antitumor effects with minimal T cell cytotoxicity. It activates CD8+ T cells and mitigates T cell exhaustion [1].
Smiles
CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C=C3)CN4CC5=CC=CC=C5C[C@@H]4C(=O)O)OC6=CC(=O)OC7=C6C=CC8=CC=CC=C87
Molecular Formula
C44H35NO6
Molecular Weight
673.75
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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